Potentiating effects of phenobarbitone on the induction of cirrhosis in rats by carbon tetrachloride
JPMA-Journal of Pakistan Medical Association. 1988; 38 (11): 296-9
Dans Anglais
| IMEMR
| ID: emr-95036
ABSTRACT
The potentiating effects of phenobarbitone sodium on the experimental induction of liver necrosis and cirrhosis by carbon tetrachloride [CCL4] were studied in 50 rats. CC14 was given by intraperitoneal injection, phenobarbitone in drinking water. Thirty rats received both agents; and 10 each received only one agent. In 7 of 10 animals given CC14alone, moderate cirrhosis without ascites developed within 6 to 8 weeks; the other 3 rats died before fourth week. All animals receiving both agents and surviving for as long as 5 to 8 weeks developed severe cirrhosis with marked proliferation of the bile ducts within 2 months. Most of these animals also had ascites. Five rats given only phenobarbitone remained healthy, although their livers increased in weight
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Indice:
Méditerranée orientale
Sujet Principal:
Tétrachloro-méthane
langue:
Anglais
Texte intégral:
J. Pak. Med. Assoc.
Année:
1988
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