Changes with age in creatinine clearance in normal subjects and the patients with different renal disorders

ABSTRACT

The endogenous creatinine clearance was studied in 33 normal subjects and in 80 patients with different renal disorders including chronic renal failure, nephrotic syndrome and renal calculi. Creatinine clearance apparently increased with advancing age in normal subjects and in the patients with renal calculi upto fourth decade after which it followed a gradual decline, but these age related changes in creatinine clearance were not found to be significant statistically. No such age related pattern of variations in creatinine clearance was observed in patients with chronic renal failure and with nephrotic syndrome. In patients with renal calculi, the values of creatinine clearance were apparently higher as compared with the normal subjects for all the age groups. On the other hand in the patients with chronic renal failure, the values of creatinine clearance were considerably lower than those seen in the normal subjects of corresponding age groups. In patients with nephrotic syndrome, the creatinine clearance was found to be significantly low [P < 0.05] as compared with the normal subjects after the age of 20 years