Acetazolamide effect on postoperative pain after laparoscopic surgery

ABSTRACT

Recently, Laparoscopic Surgery is the most helpful Surgery in the world. CO[2] insufflated to the abdominal and may cause referred pain. So the aim of this study is to determine acetazolamide effect on postoperative pain after Laparoscopic Surgery. A clinical trial, double blind study of 60 patients undergoing Laparoscopic Surgery was performed. The patient divide to 2 group. Before Surgery 250 mg Acetazolamide was administered to group A and placebo was administered to group B. Incisional pain and referred pain was voted on visual Analog Scale [0-10] at four time when first awake, 30 min after enter the recovery room, enter to surgery department and on the day after surgery. Data entered to the Spss annalistic software have been analyzed. In both two group, 7 nephrectomy, 10 varicosel, 6 orchiopexy and 7 pieloplasty have been down. Incisional pain scores not statically different [P>0.05] but the referred pain were lower after acetazolamide than after placebo. [P<0.05]. According to the result of this study, Acetazolamide reduces referred pain after Laparoscopic Surgical procedures that performed with abdominal insufflation of CO[2]