Successful treatment of biphasic metaplastic sarcomatoid carcinoma of the breast by evaluation of immunohistochemical markers
Hematology, Oncology and Stem Cell Therapy. 2010; 3 (2): 89-93
Dans Anglais
| IMEMR
| ID: emr-98067
ABSTRACT
Biphasic metaplastic sarcomatoid carcinoma [MSC] of the breast is rare and aggressive. Patients with metaplastic breast carcinomas tend to have poor outcomes with a high risk of recurrence following primary surgery. Most reports have shown that systemic therapy appears to be less effective. We report a case of a 42-year-old female who presented with a large [14 cm] cauliflower breast mass. Biopsy revealed a poorly differentiated sarcoma. Initially, neo-adjuvant concurrent chemoradiotherapy with a sarcoma regimen was prescribed, and the tumor regressed to a large ulcer. Subsequent biopsy showed invasive ductal carcinoma [estrogen receptor, progesterone receptor stained weakly, 5%, Her22+] and disappearance of the sarcomatous component. Second-line neoadjuvant therapy was designed according to the histologic features of infiltrating ductal carcinoma, which led to nearly a complete response. A modified radical mastectomy of the right breast and axillary dissection was performed followed by monoclonal antibody [trastuzumab] therapy for 6 months due to the surgical specimen showing Her23+. The treatment course went smoothly with a good response. The patient had no evidence of disease at 18 months
Recherche sur Google
Indice:
Méditerranée orientale
Sujet Principal:
Tumeurs du sein
/
Immunohistochimie
/
Marqueurs biologiques tumoraux
/
Résultat thérapeutique
Type d'étude:
Enquête cas-témoins / Études cas/témoins
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Hematol. Oncol. Stem Cell Ther.
Année:
2010
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS