Formulation and evaluation of cetirizine dihydrochloride orodispersible tablet

ABSTRACT

Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 111, 113, and 116. The flow property of granules was found to be good for the formulation CZ2 [113]. The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 [113].The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 [113]