Study of some haemostatic and inflammatory parameters in preeclamptic and normotensive pregnant females
Bulletin of Alexandria Faculty of Medicine. 2008; 44 (4): 671-675
Dans Anglais
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| ID: emr-99547
ABSTRACT
Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy characterized by gestational hypertension and proteinuria. It complicates many pregnancies and is the third common cause of maternal and neonatal mortality and morbidity. The aim of the present work was to elucidate the relationship between serum maternal levels of C-reactive protein [CRP] as an inflammatory marker and coagulation and fibrinolysis as haemostatic markers in preeclamptic and normotensive pregnant females compared to non-pregnant females. Sixty females were enrolled in the study divided into ten non pregnant healthy females as the control group [Group I], twenty five normotensive pregnant females [Group II], twenty five preeclamptic pregnant females [Group III]. The pregnant females all were primigravidae, in the third trimester of pregnancy. For all these females C-reactive protein was measured as an inflammatory marker. Haemostatic parameters included platelet count, prothrombin time, activated partial thromboplastin time and thrombin time as coagulation parameters while fibrinolytic parameter included euglobulin clot lysis time. The results showed a significant negative correlation between CRP and platelet count in preeclamptic group. It also showed a higher positive correlation between CRP and Euglobulin Clot Lysis Time [fibrinolysis parameter] in preeclampsia than in the normotensive and control groups
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Indice:
Méditerranée orientale
Sujet Principal:
Temps partiel de thromboplastine
/
Numération des plaquettes
/
Temps de prothrombine
/
Femelle
/
Protéine C-réactive
/
Grossesse
/
Étude comparative
/
Fibrinolyse
/
Hémostase
/
Inflammation
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Bull. Alex. Fac. Med.
Année:
2008
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