Inactivation of strongyloides stercoralis filariform larvae in vitro by six Jamaican plant extracts and three commercial antihelmintics
West Indian med. j
; West Indian med. j;39(4): 213-17, Dec. 1990.
Article
de En
| LILACS
| ID: lil-101047
Bibliothèque responsable:
JM3.1
ABSTRACT
In vitro bioassay of (a) aqueous methanol extracts (AME) of the green leaves of mimosa (Mimosa pudica), love weed (Cuscuta americana), vervine (Stachytarpheta jamaicensis), chicken weed (Salvia serotina) and breadfruit (Artocarpus altilis); (b) methanol-water fraction (MWF) of breadfruit leaves, and (c) commercially available drugs albendazole, thiabendazole and levamisole were assayed for nematode inactivating potential, using filariform larvae of Strongyloides stercoralis. Test larvae were obtained from a 10-day-old charcoal coproculture. Bioassays were conducted in Locke's solution, using 100 larvae in each of three replicates. Inactivation was recorded microscopically at 1, 2, 6 and 12 hours, then every 24 hours up to 5 days' incubation. It(50) (time for inactivation of 50%of larvae) values read levamisole and mimosa extract < 1 hour; love weed extract, approximately 2 hours; breadfruit (MWF), 9.5 hours; chicken weed, 20 hours; albendazole, 35 hours; breadfruit (AME), 49 hours; thiabendazole, 74 hours and vervine extract, 81.5 hours. It(95) values followed a similar trend, and were approximately double the It(50) measures. A potential role for locally available natural products in the treatment of strongyloidiasis is highlighted
Recherche sur Google
Indice:
LILACS
Sujet Principal:
Plantes médicinales
/
Strongyloides
/
Extraits de plantes
/
Anthelminthiques
Limites du sujet:
Animals
/
Humans
Pays comme sujet:
Caribe ingles
/
Jamaica
langue:
En
Texte intégral:
West Indian Med J
/
West Indian med. j
/
West Indian medical journal
Thème du journal:
MEDICINA
Année:
1990
Type:
Article