Study of the thromboxane synthetasa inhibitory effect and antiplatelet action of levamisole

RESUMO

Thromboxane A* release by guinea pig lungs stimulated by AA and ionophore A 23187 was inhibited by levamisole (40 and 120 *g/ml), whereas leukotrienes, Pgl* or PgE* generation were unaffected. Since levamisole (1,5-25 *M) also inhibited plateled aggregation induced by collagen, which is markedly T x A* dependent, we suggest that levamisole acts as a thromboxane synthetase inhibitors