Do lymphocytes play a pro-inflammatory role in any pharmacological type of rat paw edema?
Braz. j. med. biol. res
;
22(2): 179-87, 1989. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-105574
ABSTRACT
1. The hypothesis of a pro-inflammatory activity in lymphocytes related to the development of nonimmune acute inflammation was tested in leucopenic rats injected subcutaneously with various stimuli representing different pharmacological classes of paw edema-inducing agents into the subplantar area of one of the hind paws. 2. Amethopterin-induced leucopenia rendered animals hyporeactive to carrageenin and trypsin, but not to kaolin or dextran. 3. Administration of splenic lymphocytes to leucopenic rats to correct lymphopenia partially restored the inhibited responses to carrageenin and the early phase of responses to trypsin. 4. These results suggest that lymphocytes may play a pro-inflammatory role in nonimmune acute inflammation, with is more demonstrable in some pharmacological classes of paw edema than in others
Recherche sur Google
Indice:
LILAS (Amériques)
Sujet Principal:
Lymphocytes
/
Carragénane
/
Dextrane
/
Oedème
/
Inflammation
/
Kaolin
/
Leucopénie
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS