Effects of simultaneous denervation and tenotomy on the ultrastructure of a rat slow twitch muscle / Efectos de la desnervación y la tenotomía sobre la ultraestructura de un músculo fásico lento de la rata

ABSTRACT

Simultaneous denervation and tenotomy causes atrophy of rat slow twitch soleus muscle. Apparently, the alterations are similar to those seen in denervated or tenotomized slow muscle. However, the extent of disorganization of myofibrils appers lower than that expected after a moderate period of time in only denervated or tenotomized muscle. This study indicates that after an initial proliferation of lysosomes, alterations of sarcotubular system and mitochondria proceed. Nevertheless, 45 days after denervation and tenotomy many mitochondria have a normal aspect