Effect of acute footshock stress on the responsiveness of the isolated rat tail artery to phenylephrine and epinephrine
Braz. j. med. biol. res
;
25(1): 63-6, 1992. tab, ilus
Article
Dans Anglais
| LILACS
| ID: lil-109002
RESUMO
The effects of acute footshock stress on the sensitivity of the isolated rat tail artery were studied. Footshock stress applied to male Wistar rats (200-300 g) causes subsensitivity to the vasoconstrictor effects of phenylephrine and epinephrine. No significant changes in the pA2 cvalues of prozosin were detected, using epinephrine as the agonist. Footshock stress-induced subsensitivity ot epinephrine was not affected by the calcium entry blocker nifedipine. However, nifedipine significantly depressed the maximum response to epinephrine in tail arteries isolated from acute footshock-stressed rats. The present results suggest that acute footshock stress-induced reduced sensitivity to phenylephrine and epinephrine may not be only related to events at the alpha-adrenoreceptor level. The nifedipine-induced depression of the maximum response to epinephrine suggests a role for the calcium mobilization processess in the vascular responsiveness during acute stress
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Indice:
LILAS (Amériques)
Sujet Principal:
Phényléphrine
/
Artères
/
Queue
/
Épinéphrine
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1992
Type:
Article
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