The acute phase of experimental infection with Trypanosoma cruzi is more severe in mice monoassociated with strict anaerobic bacteria
Braz. j. med. biol. res
;
25(5): 491-7, 1992. ilus
Article
Dans Anglais
| LILACS
| ID: lil-109055
ABSTRACT
The influence of some components of the normal human intestinal flora on the acute phase of experimental infection with strain CL of Trypanosoma cruzi was studied in 30-day old germfree or gnotobiotic CFW (LOB) mice monassociated with Bacteroids fragilis, Peptostreptococcus sp or Clostridium sp by intragastrical inoculation of 10 6 bacteria 10 days before the intraperitoneal infections with 5 x 10 3 trypomastigotes/ g body weight. Significantly earlier parasitemia peak and mortality were observed in Bacteroides fragilis and Clostridium-associated mice (16.75 ñ 0.96 and 15.00 ñ 1.15 days, respectively) when compared with germfree animals (18.83 ñ 1.17 days). More precocious mortlity (10.40 ñ 2.06 days) and , curiouslyy, much lower blood parasitemia were observed in Peptostreptococcus-associated mice than in other gnobiotic mice. The extent of cardiac tissue parasitism decreased in the following order germfree, B. fragilis-associated, Clostridium-associated and Peptostreptococcus associated animals. The levels of inflammatory reaction decreased in the following order germfree, Peptostreptococcus-associated , Clostridium-associated, and B. fragilis-associated mice. These results show that the acute phase of experimental infection with T. cruzi was more severe in mice associated with strict anaerobic bacteria when compared with germfree animals. This suggests that a normal intestinal flora may be another factor, in addition to nutritional and genetic factors, responsible for the different susceptibility of organisms of the same species infected with T. cruzi
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Indice:
LILAS (Amériques)
Sujet Principal:
Bactéries anaérobies
/
Sang
/
Maladie de Chagas
/
Axénie
/
Infections
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1992
Type:
Article
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