Experimental coccidioidomycosis in the immunosuppressed rat
Rev. Inst. Med. Trop. Säo Paulo
;
34(4): 303-7, jul.-ago. 1992. tab
Article
Dans Anglais
| LILACS
| ID: lil-134521
RESUMO
C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Sujet immunodéprimé
/
Coccidioïdomycose
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. Inst. Med. Trop. Säo Paulo
Thème du journal:
Médecine tropicale
Année:
1992
Type:
Article
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