El proceso digestivo y la regulación de la función excretora renal: pepsanuria y procininas inhibidoras de la acción diurética del péptido natriurético auricular / Digestive process and regulation of renal excretory function: pepsanurin and prokinin inhibitors of diuretic action of atrial natriuretic peptide
Rev. méd. Chile
; 122(7): 737-45, jul. 1994. ilus
Article
de Es
| LILACS
| ID: lil-136916
Bibliothèque responsable:
CL1.1
ABSTRACT
In order to clarify the blunting effect of peptides released by pepsin from blood plasma on ANP diuretic action, 2 prokinins designated PU-16 were tested. Both of them were able to inhibit in nanomolar doses the diuretic-saluretic action of 0.5 ug i.v. bolus of ANP given to anesthetized rats either by intravenous route or introduced in the duodenal lumen. PU-16 in doses of 0.5 ug and 1 ug were able to reduce in 72 and 96.5 per cent respectively the natriuresis induced bu 0.5 ug intravenous bolus of ANP. The data support the hypothesis that prokinins liberated in the digestive tract, could be physiological factors involved in hydrosaline homeostasis, moderating the ANP mediated increase of water, Na and K excretion during digestion
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Indice:
LILACS
Sujet Principal:
Peptides
/
Facteur atrial natriurétique
/
Digestion
/
Système digestif
/
Diurèse
/
Natriurèse
Limites du sujet:
Animals
langue:
Es
Texte intégral:
Rev. méd. Chile
Thème du journal:
MEDICINA
Année:
1994
Type:
Article
/
Project document