Dispepsia no ulcerosa: relaciones entre sintomatología, gstritis y helycobacter pylori / Non ulcerative dyspepsia: relationship between symptomatology, gastritis and helycobacter pylori

ABSTRACT

Background: histological alterations of gastric mucosa and its colonization by Helicobacter pylori are postulated to be implicated in the pathogenesis of non ulcer dyspepsia. Aim: to study the possible relationships between histological gastriitis and Helicobacter pylori in non ulcer dyspepsia symptomatology. Patients and Methods: 54 patients (39 female) with non ulcer dyspepsia whose ages ranged from 17 to 68 years were subjected to an upper Gl endoscopy with gastric mucosa biopsy samples for histological study and microbiological identification of Helicobacter pylori. Gastrointestinal complains were blindy quantified using a scored questionnaire. Results: 31 subjects (57.4 per cent) had Helicobacter pylori in their gastric mucosa. There was acute inflammatory activity in 26 of the 31 patients with Helicobacter pylori (81 per cent) and 15 of 23 without Helicobacter (65 per cent). The median score of symptoms was 7 (range 2-13) in patients with Helicobacter and 6 (range 2-10= in patients without Helicobacter. Conclusions: there were no significant differences in gastric mucosa acute inflammatory activity and non ulcer dyspepsia symptomatology between patients with or without Helicobacter pylori colonization of gastric mucosa