Phospholipases C and the pathogenesis of Listeria
Braz. j. med. biol. res
;
27(2): 357-61, Feb. 1994. ilus
Article
Dans Anglais
| LILACS
| ID: lil-140275
RESUMO
Listeria monocytogenes is a model intracellular pathogen which escapes from a host cell vacuole, grows intracytoplasmically, and spreads cell to cell without an extracellular phase. A number of genes necessary for pathogenicity have been discovered, two of which encode phospholipases C, a PI-PLC and a broad-range PLC. Single and double mutants were constructed with in-frame deletions in one or both PLCs. Characterization of the strains indicated that the two PLCs may have overlapping functions as the double mutant was 500-fold less virulent while the single mutants had a negligible effect on virulence. The role of the PLCs appears to be multifactorial as PI-PLC has a role in escaping from the initial host vacuole and the broad-range PLC appears to have a role in cell to cell spreading
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Indice:
LILAS (Amériques)
Sujet Principal:
Type C Phospholipases
/
Listeria monocytogenes
Type d'étude:
Etude d'étiologie
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1994
Type:
Article
/
Congrès et conférence
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