Characterization of glycoprotein gp43, the major laminin-binding protein of Paracoccidioides brasiliensis
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;27(9): 2309-13, Sept. 1994. ilus
Article
de En
| LILACS
| ID: lil-144483
Bibliothèque responsable:
BR1.1
RESUMO
We have demonstrated that laminin mediates the adhesion of P. brasiliensis to monolayers of epithelial cells through specific binding to the surface glycoprotein gp43. This binding seems to be related to the fungal pathogenesis. We now report the confirmation of these findings by scanning electron microscopy and show that some isolates that do not secrete gp43 do express the protein as seen studying whole cell extracts. This results confirm the ability of these strains to produce paracoccidioidomycosis but should not be used for serological purposes since the absence of gp43 in exoantigens may lead to false negative results:
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Indice:
LILACS
Sujet Principal:
Paracoccidioides
/
Protéines fongiques
/
Glycoprotéines membranaires
/
Laminine
Limites du sujet:
Animals
Pays comme sujet:
America do sul
/
Brasil
langue:
En
Texte intégral:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Thème du journal:
BIOLOGIA
/
MEDICINA
Année:
1994
Type:
Article
/
Congress and conference
/
Project document