Effects of a single administration of buspirone on catalepsy, yawning and stereotypy in rats
Braz. j. med. biol. res
;
26(1): 71-4, Jan. 1993. tab
Article
Dans Anglais
| LILACS
| ID: lil-148675
ABSTRACT
In the present study, the effects of a single administration of buspirone (0.1, 0.3, 1.0, and 3.0 mg/kg sc-30 min before testing) on three dopamine-related behaviors were evaluated in 4-month old male Wistar rats (7-10 animals per group). Buspirone decreased haloperidol (2.0 mg/kg ip)-induced catalepsy in a dose-dependent manner (from 7.30 to 5.09 1n of s compared to the untreated control group). Apomorphine (0.06 mg/kg sc)-induced yawning was also dose-dependently reduced (from 26.7 to 0.9 yawns in 30 min) and so was apomorphine (1.0 mg/kg sc)-induced stereotypy (from 32.9 to 5.9, sum of scores). The present results indicate that buspirone presents unique pharmacological effects related to dopaminergic transmission not only in biochemical but also in behavioral terms
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Indice:
LILAS (Amériques)
Sujet Principal:
Comportement stéréotypé
/
Buspirone
/
Catalepsie
/
Bâillement
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1993
Type:
Article
/
Congrès et conférence
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