Attenuation of behavioral consequences of immobilization stress by intra-hippocampal microinjection of zimelidine
Braz. j. med. biol. res
;
26(10): 1085-9, Oct. 1993. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-148785
ABSTRACT
To investigate the role of hippocampal 5-HT neurotransmission on adaptation to aversive events, individually housed male Wistar rats (200-250 g) were immobilized for 2 h and tested 24 h later in an elevated plus-maze. Immediately after the restraint period they received bilateral microinjections into the dorsal hippocampus of either saline (0.5 microliters) or the nonselective 5-HT1 antagonist dl-propranolol (20 nmol/0.5 microliters). In a second experiment the first microinjection of saline or dl-propranolol was followed by a second microinjection of saline (0.5 microliters) or the 5-HT reuptake blocker zimelidine (20 nmol/0.5 microliters). Although dl-propranolol alone did not change exploration of the elevated plus-maze, it antagonized the increase in the percentage of open arm entries induced by zimelidine (26.0 +/- 4.1 vs 5.64 +/- 3.7 in controls). These results are compatible with the view that post-synaptic 5-HT1a receptors in the hippocampus mediate adaptive or coping responses to aversive events
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Indice:
LILAS (Amériques)
Sujet Principal:
Contention physique
/
Sérotonine
/
Récepteurs sérotoninergiques
/
Zimeldine
/
Comportement d'exploration
/
Hippocampe
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1993
Type:
Article
/
Congrès et conférence
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