Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart.)
Mem. Inst. Oswaldo Cruz
;
88(4): 599-603, Oct.-Dec. 1993. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-148848
RESUMO
The lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Eczéma de contact
/
Lectines
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
1993
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS