Protective effect of Saccharomyces boulardii against the cholera toxin in rats
Braz. j. med. biol. res
;
28(3): 323-5, Mar. 1995. ilus
Article
Dans Anglais
| LILACS
| ID: lil-154697
ABSTRACT
The effect of orogastric administration of Saccharomyces boulardii on the anatomopathological aspect of the jejunal villi was studied in male Fischer rats (weighing about 40 g) orogastrically infected with a culture of Vibrio cholerae. Experimental and control groups received lyophilized S. boulardii (25 mg suspended in 0.5 ml saline) or 0.5 ml saline, respectively, three times a day for 10 days by gastric intubation. On day 5 of treatment, 0.5 ml of a culture of V. cholerae containing 10(8) viable cells was inoculated by gastric intubation into both groups. Histopathological examination of the jejunal mucosa showed extensive lesions of the superficial epithelium of the villi from the control group whereas few lesions of this superficial epithelium were observed in the experimental group. These data show that the inhibition of the action of the cholera toxin on enterocytes by S. boulardii suggested by recent results in vitro can be demonstrated in vivo
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Indice:
LILAS (Amériques)
Sujet Principal:
Saccharomyces
/
Vibrio cholerae
/
Toxine cholérique
/
Muqueuse intestinale
/
Jéjunum
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1995
Type:
Article
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