V3 peptide binding pattern and HIV-1 transmission route in Rio de Janeiro
Mem. Inst. Oswaldo Cruz
;
90(6): 683-5, Nov.-Dez. 1995.
Article
Dans Anglais
| LILACS
| ID: lil-158730
RESUMO
To characterize antibody binding to a panel of V3 loop peptides representing diverse HIV-1 neutralization epitopes, 149 HIV-1 infected individuals from Rio de Janeiro (RJ) were investigated. Results were analyzed with respect to risk factors for infection and other epidemiological and clinical data. Peptide reactivity was not associated with sex, clinical status, CD4 counts, antigenemia or ß2-microglobulin serum level. A segregation of peptide reactivity according to route of infection was encountered. This finding suggests that more then one viral strain may be circulating in RJ, in subjects with different risk factors for HIV-1 infection. An investigation of prevalent HIV-1 genotypes, serotypes and immunotypes may be of importance for the design and selection of potential vaccines to be used in Brazil as well as for the selection of populations to be included in future vaccine efficacy trials.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Fragments peptidiques
/
Anticorps anti-VIH
Type d'étude:
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
1995
Type:
Article
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