Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy
Arch. med. res
; Arch. med. res;24(1): 1-6, mar. 1993. ilus, tab
Article
de En
| LILACS
| ID: lil-176994
Bibliothèque responsable:
MX1.1
ABSTRACT
Forty unrelated Mexican patients with Duchenne/Backer muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone oxons described by Chamberlain et al. and beggs et al. The percentage of deletions was 52.5 percent, and the majority of them (86.3 percent) were located at the hot spot deletion region which encompasses exons 44 - 55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity
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Indice:
LILACS
Sujet Principal:
Population
/
Prévision démographique
/
Génétique des populations
/
Maladies génétiques congénitales
/
Dystrophies musculaires
Limites du sujet:
Adolescent
/
Female
/
Humans
/
Male
Pays comme sujet:
Mexico
langue:
En
Texte intégral:
Arch. med. res
Thème du journal:
MEDICINA
Année:
1993
Type:
Article