Prevention of preeclampsia with calcium supplementation and its relation with L-arginine: citric oxide pathway
Braz. j. med. biol. res
;
29(6): 731-41, jun. 1996. tab
Article
Dans Anglais
| LILACS
| ID: lil-181407
ABSTRACT
Pregnancy-induced hypertension (PIH) remains a common cause of maternal and fetal morbidity and mortality. During the past 7 years, some progress has been made in the prevention of PIH. Specifically, clinical studies have shown that supplementation with calcium can significantly reduce the frequency of PIH, especially in populations with a low calcium intake. We have suggested that, in such a population, calcium supplementation is a safe and effective measure for reducing the incidence of PIH. Calcium supplementation reduces the risk of PIH by maintaining the serum ionized calcium level which is crucial for the production of endothelial nitric oxide, the increased generation of which maintains the vasodilatation that is characteristic of normal pregnancy. In PIH there is an impaired nitric oxide synthesis and cyclic GMP production.
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Indice:
LILAS (Amériques)
Sujet Principal:
Pré-éclampsie
/
Complications cardiovasculaires de la grossesse
/
Aliment enrichi
/
Calcium
/
Hypertension artérielle
Limites du sujet:
Femelle
/
Humains
/
Grossesse
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1996
Type:
Article
/
Congrès et conférence
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