D-Fenfluramine selectively releases 5-HT from dorsal raphe terminals
Braz. j. med. biol. res
;
29(5): 639-42, May 1996. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-182548
ABSTRACT
The aim of this study was to investigate whether D-fenfluramine (FEN) releases 5-hydroxytryptamine (5-HT) selectively from dorsal raphe (DR) terminais. Male Wistar rats, 180-200 g, were implanted with microdialysis probes in the amygdala (Am; N = 5) and dorsal hippocampus (DH; N = 6) and 5-HT levels were measured by electrochemical detection. Under basal conditions, 5-HT levels were approximately 50 and 230 fmol per 30 min sample, in the Am and DH, respectively. FEN (1O mg/kg, ip) produced a 3-4-fold increase in 5HT relesse in the Am, but not in the DH. Since the Am is mainly innervated by DR fibers while the DH receives 5-HT input chiefly from the median raphe (MR), the present results support the view that FEN selectively releases 5-HT from DR terminals.
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Indice:
LILAS (Amériques)
Sujet Principal:
Noyaux du raphé
/
Sérotonine
/
Fenfluramine
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1996
Type:
Article
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