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Possible modulatory role of non-activated lymphocytes on insulin secretion
Braz. j. med. biol. res ; 29(12): 1709-13, Dec. 1996. graf
Article Dans Anglais | LILACS | ID: lil-188458
ABSTRACT
In order to study the probable physiological role of non-activated lymphocytes on islet B-cells, we incubated and perfused rat pancreatic islets in the presence of low (2.8 mM) and high (l6.7 mM) glucose concentrations after pre-exposure for 60 min to rat lymphocytes or to substances secreted by lymphocytes. Insulin secretion and 86Rb+, 45Ca2+ and [3H]-phosphoinositide metabolite fluxes were lower compared to controls when islets were pre-exposed to lymphocytes but were not different when islets were pre-exposed to substances secreted by lymphocytes. These alterations in isotope flux suggest that, when lymphocytes and islets are in contact, closure of potassium channels and a paradoxical effect of glucose load on insulin release occur in the presence of low glucose concentrations. The alterations observed are probably due to a swift and direct action of lymphocyte secretion perhaps induced by a direct contact of islet cells.
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Indice: LILAS (Amériques) Sujet Principal: Techniques in vitro / Lymphocytes / Insuline Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1996 Type: Article / Congrès et conférence / descriptif de projet

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Indice: LILAS (Amériques) Sujet Principal: Techniques in vitro / Lymphocytes / Insuline Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1996 Type: Article / Congrès et conférence / descriptif de projet