Análisis de paternidad en casos de incesto, utilizando polimorfismo del ADN de loci multialélicos / Paternity analysis in incest cases using DNA polymorphisms of multiallelic loci

ABSTRACT

The analysis of genetic markers in man allows to efficiently resolve cases of dubious paternity. Lately, the use of genetic markers derived from DNA analysis allows high exclusion probabilities. A particular case are those consultations whom the progenitors are closely related, in which the criteria to attribute paternity are modified. The present report explains the analysis methods and interpretation of results in situations of doubtful paternity in cases of incest between father and daughter, using monolocus DNA polymorphisms. The method is illustrated through the analysis of 4 cases seen at the Servicio Médico Legal of Santiago. To be able to determine paternity in these cases of incest, at least three multiallelic loci in which mother and son have different genotypes must be examined