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Marcadores de fibrogénesis hepática en pacientes alcohólicos / Hepatic fibrogenesis markers in alcoholic patients
Rev. méd. Chile ; 125(1): 15-21, ene. 1997. tab
Article Dans Espagnol | LILACS | ID: lil-194518
RESUMO
Serum P-III-P and laminim levels were measured in asymptomatic alcoholics during detoxication treatment. Liver biopsies were obtained, in order to detect liver damage, which was graded with a numeric score, considering values over 6 as severe damage. Serum fibrogenesis markers were also measured in a group of decompensated alcoholic cirrhotics. P-III-P levels were significantly higher in cirrhotic patients compared to alcoholics with or without liver damage and to normal controls. Laminin was not different between groups. P-III-P did not correlate with histological score in asymptomatic patients. In this study P-III-P and P1 laminin were not usefull discriminators of severe liver damage among asymptomatic alcoholics; their levels were found to rises significantly only when liver disease has become clinically evident
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Indice: LILAS (Amériques) Sujet Principal: Marqueurs biologiques / Alcoolisme / Cirrhose alcoolique Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 1997 Type: Article / descriptif de projet

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Indice: LILAS (Amériques) Sujet Principal: Marqueurs biologiques / Alcoolisme / Cirrhose alcoolique Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 1997 Type: Article / descriptif de projet