Estudio de factores genéticos en la agregación familiar de la esquizofrenia en Santiago, Chile / Genetic factors study in family aggregation of schizophrenia in Santiago, Chile

RESUMO

Forty four randomly selected schizophrenic probands, 22 female, aged 28 to 48 years old, were studied. From them, an extensive genealogic reconstruction was performed. Probands and relatives were interviewed using the structured interview CIDI and DSM-III-R check list. Schizophrenia was diagnosed using DSM-III-R criteria. Complex segregation analysis was done using Pointer program. The hypothesis of a multifactorial inheritance, without the participation of major genes, could not be rejected. Likewise, the major dominant and co-dominant gene forms of transmission could not be rejected. Our results show the participation of a major dominant locus and a multifactorial component in the inheritance of schizophrenia, as has been reported elesewhere