Malnutrition and brain function: experimental studies using the phenomenon of cortical spreading depression
Rev. bras. biol
;
56(supl.1,pt.2): 293-301, dez. 1996. graf
Article
Dans Anglais
| LILACS
| ID: lil-196349
RESUMO
Depending on its intensity and duration, nutritional deficiency can disrupt the structure and function of the nervous system of humans and other mammals, with consequences more or less devastating for the whole organism, particularly in the early postnatal life, when body growth is very rapid and the need for proteins, calories and other nutrients is greatest. In this review, electrophysiological data are presented regarding the use of the phenomenon of cortical spreading depression (CSD) to study effects of malnutrition on the brain. Several conditions of clinical importance and that are known to alter brain function are shown also to influence CSD features in experimental animals. Some of these conditions, (e.g., phamacological manipulation of neurotransmitter systems, dietary treatment with Lithium, acute hyperglycemia, hypothyroidism, aging and environmental stimulation) decrease CSD susceptibility, while other conditions increase it, as, for example, systemic reduction of extracellular chloride levels, deprivation of REM-sleep, acute hypoglycemia, treatment with diazepam, consumption of ethanol and malnutrition. Particular emphasis is laid on the effect of early environmental enrichment on CSD in normal and malnourished animals. Our results suggest that such effect is more evident in the malnourished brain, as compared to the wellnourished one. The data also show that malnutrition alters the brain responsivity to some CSD-facilitatory or inhibitory agents. The underlying mechanisms to explain the observed effects are discussed.
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Indice:
LILAS (Amériques)
Sujet Principal:
Dépression corticale envahissante
/
Encéphale
/
Troubles nutritionnels
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. bras. biol
Thème du journal:
Biologie
Année:
1996
Type:
Article
/
Congrès et conférence
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