Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models
Braz. j. med. biol. res
;
30(8): 971-9, Aug. 1997. graf
Article
Dans Anglais
| LILACS
| ID: lil-197254
RESUMO
The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor N(G)-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by sound drugs such as pilocarpine and pentylenetetrazole (PTZ) and by stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic componentes of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interations with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Nitric oxide synthase
/
Convulsivants
/
Modèles animaux de maladie humaine
/
Épilepsie
/
Anticonvulsivants
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1997
Type:
Article
/
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