Prevalence of antibodies to the repeat epitope of the circumsporozoite protein of Plasmodium vivax in San Luis Potosi, Mexico
Arch. med. res
;
27(2): 233-6, 1996. tab, ilus
Article
Dans Anglais
| LILACS
| ID: lil-200320
RESUMO
The prevalence of antibodies against the repeat epitope of the circumsporozoite protein (cs) of the standard (PV210) and variant (PVK247) strain of Plasmodium vivax was determined by ELISA in 1170 sera from individual residents of seven localities of the Region Huasteca of San Luis Potosi, Mexico. The capture antigens were the synthetic peptides DDAAD and (ANGAGNQPG)4 that correspond to the repeats of the PV210 and PVK247 cs proteins, respectively. Of the analyzed serum samples, 34.1 percent (400/1170) were positive with one or both of these antigens. Of the sera, 18.2 percent (214/1170) reacted with the DDAADF peptide and 6.6 percent (78/1170) were positive with the variant synthetic peptide. Additionally, 9.2 percent (108/1170) of the samples reacted with both peptides. A sample of 10 percent of positive sera for the variant cs repeat (18/78) was tested with the cs repeat peptide of P. malariae/P. brasilianum (NAAG); almost all of them (16/18, 89 percent) being positive. These results confirm that the transmission of the variant strain of P. vivax is a common Phenomenon in endemic regions in Latin America, as well as in other tropical regions of the world. These findings may have implications for the development of a P. vivax vaccine since that based on the standard cs repeat only would not be universally protective
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Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium vivax
/
Test ELISA
/
Protéines de protozoaire
/
Vaccins contre le paludisme
/
Mexique
/
Épitopes
Type d'étude:
Étude de prévalence
/
Facteurs de risque
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
Arch. med. res
Thème du journal:
Médicament
Année:
1996
Type:
Article
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