Antibody response of Mexican infants to Haemophilus influenzae type b capsular polyribosylribitol phosphate. Differences between natural and vaccine induced (Oligosaccharide-CRM197 conjugated vaccine) immunization
Arch. med. res
;
27(4): 539-45, 1996. tab
Article
Dans Anglais
| LILACS
| ID: lil-200360
RESUMO
In this study we compared natural vs induced Haemophilus influenzae type b (hib) anti-capsular polyribosylribitol phosphate (PRP) antibody response in a low socioeconomic population. One hundred twenty five 2-month-old children received the complete HbOC vaccine immunization scheme and a boster dose at 15 month of age. One hundred twenty five non-immunized children served as the control group. Serum Hib anti-PRP antibody titers were determuined by ELISA in all children. We found at the end of the primary immunization scheme an antibody concentration of 27.28 µg/ml in the immunized group vs. 7.48 µg/ml in the control group. The antibody response was mainly of the IgG1 class in both groups. After the booster dose the antibody concentration was 30.14 g/ml in the vaccinated group vs. 6.06 µg/ml in the control group (p<0.01). Ninety nine percent of immunized and non-immunized infants had titers greater than 1 µg/ml. These results confirm that immunization with the HbOC vaccine induces an important increase in anti-PRP specific antibody titer, but they also demonstrate that natural exposure induces responses higher than those referred as protective (1 µg/ml)
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Indice:
LILAS (Amériques)
Sujet Principal:
Oligosaccharides
/
Phosphates
/
Sérologie
/
Test ELISA
/
Vaccins
/
Haemophilus influenzae
/
Vaccins conjugués
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Femelle
/
Humains
/
Bébé
/
Mâle
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
Arch. med. res
Thème du journal:
Médicament
Année:
1996
Type:
Article
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