Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;30(10): 1191-7, Oct. 1997. tab, graf
Article
de En
| LILACS
| ID: lil-201537
Bibliothèque responsable:
BR1.1
ABSTRACT
A study was conducted on mice infected with strains Y and CL of Trypanosoma cruzi. The ability of anti-Y and anti-CL sera to induce complement-mediated lysis, immune clearance and protection against the acute phase of the infection was studied using homologous anti-Y or anti-CL serum tested with the Y or CL strain, or heterologous anti-Y serum tested with the CL strain or anti-CL serum tested with the Y strain. Complement-mediated lysis was induced by both homologous and heterologous antisera but protection was afforded only by homologous antisera. Immune clearance was induced by homologous but not by heterologous antisera. Antisera with high clearance ability were able to confer protection whereas antisera with high lytic ability were not. These results show a high correlation between the antibody ability to induce clearance and to confer protection and suggest that clearance rather than lysis is responsible for protection against the acute phase of the infection. The mechanisms of antibody protection against the acute phase of the infection is discussed.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Trypanosoma cruzi
/
Trypanosomiase
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Modèles animaux de maladie humaine
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Anticorps
Limites du sujet:
Animals
langue:
En
Texte intégral:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Thème du journal:
BIOLOGIA
/
MEDICINA
Année:
1997
Type:
Article