Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases
São Paulo med. j
;
115(6): 1575-9, nov.-dez. 1997. tab
Article
Dans Anglais
| LILACS
| ID: lil-209324
ABSTRACT
Objective:
To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD).Design:
Retrospective study.Setting:
Public tertiary referral center. Patients Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 with idiopathic myelofibrosis (MF). Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals.Results:
Eleven patients presented symptoms (41 percent) 9 with hemorrhage (33 percent) and 5 with thrombosis (19 percent). There were less symptomatic patients in the CML group (28 percent) than in the other MPD (67 percent), without statistical significance (Fisher, p=0.06). Duke's BT was longer in symptomatic patients (Mann-Whitney, p<0.05). Platelet aggregation was abnormal in 7 patients (26 percent) and 71 percent of them were symptomatic (Fisher, p=0.07)Conclusions:
The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Thrombose
/
Temps de saignement
/
Épinéphrine
/
Agrégation plaquettaire
/
Hémorragie
/
Syndromes myéloprolifératifs
Type d'étude:
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
São Paulo med. j
Thème du journal:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Médicament
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Année:
1997
Type:
Article
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