Idiopathic focal segmental glomerulosclerosis and HLA antigens
Braz. j. med. biol. res
;
31(3): 387-9, Mar. 1998.
Article
Dans Anglais
| LILACS
| ID: lil-212274
ABSTRACT
The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS), HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2 percent, P<0.05). In addition, the three patients of Japanase extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this disease.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Glomérulonéphrite segmentaire et focale
/
Antigènes HLA
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1998
Type:
Article
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