Brevetoxin-3 (PbTx-3) on mouse liver slices: a histological study
P. R. health sci. j
;
15(4): 261-7, dec. 1996. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-212516
ABSTRACT
Brevetoxin-3 (PbTx-3) is a marine toxin produced by the dinoflagellate Ptychodiscus brevis. Its effects on excitable tissues have been the main subject of studies, but little is known about how it affects non-excitable tissues. To study possible non-neural effects of PbTx-3 (78nM), its effects on hepatic cell structure in vitro were evaluated. PbTx-3 caused hypertrophy and increased vacuolation of hepatocytes, and an increase in basophilia in the perivenous area of the lobules. Ultrastructurally, it was evident that the vacuolation was related to swelling of the endoplasmic reticulum, changes that probably account for the increased basophilic reaction of the cells. The swelling in smooth endoplasmic reticulum, degranulation of rough endoplasmic reticulum, the deformities and lytic cristae in the mitochondria, and the presence of active lysosomes are evidence of the PbTx-3 effects upon liver cells. These responses are probably caused by the liver's detoxification role on the PbTx-3.
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Indice:
LILAS (Amériques)
Sujet Principal:
Dinoflagellida
/
Techniques in vitro
/
Foie
/
Toxines de la flore et de la faune marines
/
Neurotoxines
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
P. R. health sci. j
Thème du journal:
Médicament
Année:
1996
Type:
Article
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