Immunologic patterns associated with cure in human American cutaneous leishmaniasis
Braz. j. med. biol. res
;
31(1): 139-42, Jan. 1998.
Article
Dans Anglais
| LILACS
| ID: lil-212550
ABSTRACT
Patients with American cutaneous leishmaniasis were studied before therapy (active lesion) and at the end of therapy (cured patients). Assays of lymphocyte proliferative responses of peripheral blood mononuclear cells induced in vitro by Leishmania braziliensis promastigote antigens (Lb) were performed. Antigen-stimulated cells were harvested for CD4 and CD8 phenotype analysis and the levels of gamma interferon (IFN-gamma) and interleukin 4 (IL-4) produced were also determined in the culture supernatants. Two different patterns of Lb-induced T cell responses were observed a) predominance of responding CD4+ cells and mixed type 1 and type 2 cytokine production (IFN-gamma and IL-4) during the active disease, and b) similar proportions of responding CD4+ and CD8+ cells, and type 1 cytokine production (presence of INF-gamma and very low IL-4) at the end of therapy (healed lesions). This last pattern is probably associated with a beneficial T cell response.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Leishmaniose cutanée
Type d'étude:
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1998
Type:
Article
/
Congrès et conférence
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