The use of non-human primates as animal models for the study of hepatitis viruses
Braz. j. med. biol. res
;
31(8): 1035-48, Aug. 1998. tab
Article
Dans Anglais
| LILACS
| ID: lil-216826
ABSTRACT
Hepatitis viruses belong to different families and have in common a striking hepatotropsin and restrictions for propagation in cell culture. The transmissibility of hepatitis is in great part limited to non-human primates. Enterically transmitted hepatitis viruses (hepatitis A virus and hepatitis E virus) can induce hepatitis in a number of OLD World and New Worls monkey species, while the host range of non-human primates susceptible to hepatitis viruses transmitted by the parenteral route (hepatitis B virus, hepatitis C virus and hepatitis delta virus) is restricted to few species of Old World monkeys, especially the chimpanzee. Experimental studies on non-human primates have provided an invaluable source of information regarding the biology and pathogenesis of these viruses, and represent a still indispensable tool for vaccine and drug testing.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cebidae
/
Cercopithecidae
/
Modèles animaux de maladie humaine
/
Hépatite virale animale
/
Virus de l'hépatite
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1998
Type:
Article
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