Productos naturales del bosque humedo tropical de Venezuela, inhibidores de la replicacion de VIH-1 / Natural products from the amazonian rainforest of Venezuela as inhibitors of HIV-1 growth
Acta cient. venez
;
46(2): 110-4, 1995. tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-217136
RESUMO
More than 100 plant extracts from the Amazonian rain forest of Venezuela were evaluated for their cytotoxicity and inhibitory activity against the human immunodeficiency virus type-1 (HIV-1). Aqueous extracts from Fomitella supina (S # 0389-4), Phellinus rhabarbarinus (S # 0389-7), Trichaptum perrottetti (S # 0389-8) and Trametes cubensis (S # 0389-13), Polyporaceae exhibited strong anti-HIV-1 activity, without toxicity for Molt-4 lymphocytic cells. Our results demonstrated, that the compound(s) acted by mechanism of direct virion inactivation and by inhibition of syncytium formation in an in vitro culture system. These results support the suggestion that the test extracts specifically act at the level of CD4-gp120 binding. The active components of these extracts is at present unknown, but anti-AIDS agents, such as those found in this study, individually or in combination, may be of therapeutic relevance
Recherche sur Google
Indice:
LILAS (Amériques)
Sujet Principal:
Antiviraux
/
Réplication virale
/
Extraits de plantes
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Vénézuela
langue:
Espagnol
Texte intégral:
Acta cient. venez
Thème du journal:
Science
Année:
1995
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS