Gender differences in the activities of aspirin-esterases in rat tissues
Braz. j. med. biol. res
;
31(9): 1113-8, sept. 1998. tab
Article
Dans Anglais
| LILACS
| ID: lil-222957
ABSTRACT
The activities of aspirin (acetylsalicylic acid)-esterases were measured in several tissues (liver, kidney, adrenal glands, brain and serum) from adult male and female Wistar rats. In males, both aspirin-esterase I (assayed at pH 5.5) and II (assayed at pH 7.4) activities were higher in liver homogenates when compared to females (aspirin-esterase I males 48.9 ñ 4.8 (N = 8) and females 29.3 ñ 4.2 (N = 8) nmol of salicylic acid formed min-1 mg protein-1; aspirin-esterase II males 41.4 ñ 4.1 (N = 8) and females 26.1 ñ 4.5 (N = 8) nmol of salicylic acid formed min-1 mg protein-1, P<0.001). In serum, enzyme activity was higher in females than in males (aspirin-esterase I males 0.85 ñ 0.06 (N = 6) and females 1.18 ñ 0.11 (N = 6) nmol of salicylic acid formed min-1 mg protein-1; aspirin-esterase II males 1.03 ñ 0.13 (N = 6) and females 1.34 ñ 0.11 (N = 6) nmol of salicylic acid formed min-1 mg protein-1, P<0.001). In the other tissues assayed, no statistically significant difference between males and females was found. There were no statistically significant differences when the enzymes were assayed in different phases of the estrous cycle in liver and serum. These results show that the differences in aspirin-esterase activity observed between males and females are not due to the estrous cycle. The gender difference obtained in our study may indicate an involvement of gonadal hormones in the control of the hydrolysis of aspirin. This possibility is currently under investigation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Différenciation sexuelle
/
Carboxylic ester hydrolases
/
Acide acétylsalicylique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1998
Type:
Article
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