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Telomerase activity in thymomas and mammary gland adenocarcinomas induced by polyoma virus in AKR mice
Medicina (B.Aires) ; 58(5,pt.1): 497-500, 1998. ilus
Article Dans Anglais | LILACS | ID: lil-224403
ABSTRACT
Telomerase is an enzyme that stabilizes telomere lenght in transformed cells and tumors. Its role in tumor development is far from clear. In this paper, a new experimental model to study telomerase activity during tumorigenesis is presented. After infection with Polyoma virus, AKR mice developed thymomas and mammary gland adenocarcinomas. Polyoma antigens were observed by the peroxidase-antiperoxidase technique on tissue sections, and by Western blot on tumor extracts. The TRAP assay was performed to detect telomerase activity. It was not present in normal mammary gland, but it was positive in mammary gland adenocarcinomas. A different pattern was seen in thymic tissues normal thymus had higher telomerase activity than thymomas. The incubation of thymoma extracts with normal thymus extracts decreased telomerase activity in the latter. These results demonstrate two different patterns of telomerase activity in tumors induced by Polyoma virus, and suggest the presence of telomerase inhibitory factors in thymomas.
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Indice: LILAS (Amériques) Sujet Principal: Thymome / Tumeurs du thymus / Infections à virus oncogènes / Adénocarcinome / Polyomavirus / Telomerase / Infections à papillomavirus / Tumeurs expérimentales de la mamelle Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Medicina (B.Aires) Thème du journal: Médicament Année: 1998 Type: Article / Congrès et conférence

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Indice: LILAS (Amériques) Sujet Principal: Thymome / Tumeurs du thymus / Infections à virus oncogènes / Adénocarcinome / Polyomavirus / Telomerase / Infections à papillomavirus / Tumeurs expérimentales de la mamelle Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Medicina (B.Aires) Thème du journal: Médicament Année: 1998 Type: Article / Congrès et conférence