Metabolic profile and insulin sensistivity in healthy young mexicans with a strong family history of non-insulin-dependent diabetes mellitus in the paternal branch
Arch. med. res
;
28(3): 421-4, sept. 1997. tab
Article
Dans Anglais
| LILACS
| ID: lil-225248
ABSTRACT
The objective was to identify early metabolic defects and insulin sensitivity in a group of healthy young Mexicans with a family history of NIDDM in first and second degree on the paternal branch. The design was a cross-sectional study, and the setting was a hospital and a school of medicine in Guadalajara, Jalisco, Mexico. The subjects were 20 healthy, non-obese, young (age 19-20 years), born in Mexico, with family history of NIDDM in first and second degree in the paternal branch, and 20 control. Measurements were serum values of creatinin, uric acid, total cholesctero, high-density lipoprotein cholestero, triglycerides, glucose, and insulin, insulin tolerance test, glucose/insulin ratio, LDL cholesterol, VLDL cholesterol, total cholesterol/HDL cholesterol ratio and LDL clolesterol/HDL cholesterol ratio. In terms of results, only the total cholesteroa was slightly, although significantly )p=0.05) higher in probands (4.3 ñ 0.5 mmol/L) than in control subjects (3.9 ñ 0.5 mmol/L). In conclusion, healthy young Mexicans with astrong family history of NIDDM in the paternal branch were no different in insulin sensitivity from those without family history of NIIDM, and only showed a slight increase in serum total cholesterol
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Indice:
LILAS (Amériques)
Sujet Principal:
Parents
/
Cholestérol
/
Diabète de type 2
/
Insuline
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
Arch. med. res
Thème du journal:
Médicament
Année:
1997
Type:
Article
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