CA 15.3 in breast cancer: Comparison of two assays and validation in a mexican population
Arch. med. res
;
28(4): 523-6, dec. 1997. tab
Article
Dans Anglais
| LILACS
| ID: lil-225257
ABSTRACT
Ca 15.3 is a tumor marker used for breat carcinoma, since one epitope is an antigen present in milk fat globules. Serum from 171 patients withbreast cancer upon initial presentation was studied for Ca 15.3. In the first 72 cases, the authors compared RIA vs. ELISA using a simple linear regression. On the following 99, only ELISA was performed. With all 171 patients, a clinical association between Ca 15.3 mesurement and age, stage and hormone receptors was carried out. Correlation coefficient between RIA and ELISA was 0.85. Of 104 patients below 50 years of age, 88 had normal Ca 15.3 and 16, elevated; 67 were older than 50 years, 46 had normal Ca 15.3 and 21, elevated (p=0.022). Ca 15.3 was elevated in 11 percent of patients with clinical stages I/II, and 89 percent in stages III/IV (p=0.0001). The association of Ca 15.3 with hormone receptors was not significant. In conclusion, ELISA and RIA measure Ca 15.3 with comparable results, the first method has the advantage of not using radioactivity. The authors found higher probability of elevated Ca 15.3 in older patients and in those with advanced disease
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Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs du sein
/
Test ELISA
/
Dosage radioimmunologique
/
Marqueurs biologiques tumoraux
/
Reproductibilité des résultats
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
Arch. med. res
Thème du journal:
Médicament
Année:
1997
Type:
Article
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