Asociación entre la variación genética de MSX1 (Hox-7) y la fisura labiopalatina no sindrómica en población chilena / Association between the genetic variation of MSX1 (Hox-7) and non syndromic cleft lip palate in chilean subjects
Rev. méd. Chile
;
126(6): 637-45, jun. 1998. ilus, tab
Article
Dans Espagnol
| LILACS
| ID: lil-229005
ABSTRACT
Background:
Homeotic genes have regulatory functions during development. It has been postulated that the human Msx-1 homeotic gene can be involved in the etiology of non syndromic cleft lip palate, since its homologous Msx-1 is involved in cleft palate of mice.Aim:
To perform an association analysis between the genetic variation of Msx-1 and non syndromic cleft lip palate in Chilean subjects. Patients andmethods:
Seventy patients with non syndromic cleft lip palate, 136 healthy relatives of these patients and 69 non related normal individuals were studied. CA microsatellite in Msx- gene, that was amplified with PCR, was studied.Results:
No differences in the genetic frequencies of Msx-1 alleles, were observed in the three groups studied. Allelic heterogeneity for allele 2 seems to be related to cases of non syndromic cleft lip palate from multiplex families and heterogeneity for allele 3 is related with simplex families cases.Conclusions:
These results seem to support the hypothesis of genetic heterogeneity in the etiology of non syndromic cleft lip palate
Recherche sur Google
Indice:
LILAS (Amériques)
Sujet Principal:
Bec-de-lièvre
/
Fente palatine
/
Allèles
/
Modèles génétiques
Type d'étude:
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
1998
Type:
Article
/
descriptif de projet
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS