Actividad de diterpenoides de azorella compacta, llareta, sobre amastigotes de trypanosoma cruzi / Activity of dipernoids isolated from azorella compacta, llareta, on trypanosoma cruzi amastigotes
Bol. chil. parasitol
;
53(1-2): 9-13, ene.-jun. 1998. ilus, tab
Article
Dans Espagnol
| LILACS
| ID: lil-233091
ABSTRACT
The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta. Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhitory concentration 50 (IC) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC between 41 µM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet
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Indice:
LILAS (Amériques)
Sujet Principal:
Plantes médicinales
/
Trypanosoma cruzi
Limites du sujet:
Humains
langue:
Espagnol
Texte intégral:
Bol. chil. parasitol
Thème du journal:
ALIMENTOS
/
Parasitologie
Année:
1998
Type:
Article
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