Functional analysis of newly discovered growth control genes: experimental approaches
Braz. j. med. biol. res
;
32(7): 867-75, July 1999.
Article
Dans Anglais
| LILACS
| ID: lil-234893
RESUMO
A large number of DNA sequences corresponding to human and animal transcripts have been filed in data banks, as cDNAs or ESTs (expression sequence tags). However, the actual function of their corresponding gene products is still largely unknown. Several of these genes may play a role in regulation of important biological processes such as cell division, differentiation, malignant transformation and oncogenesis. Elucidation of gene function is based on 2 main approaches, namely, overexpression and expression interference, which respectively mimick or suppress a given phenotype. The currently available tools and experimental approaches to gene functional analysis and the most recent advances in mass cDNA screening by functional analysis are discussed
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Expression des gènes
/
Éléments antisens (génétique)
/
ARN catalytique
/
Transgènes
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1999
Type:
Article
/
Congrès et conférence
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