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Immunopathology of cardiomyopathy in the experimental Chagas disease
Soares, Milena B. P; Santos, Ricardo Ribeiro dos.
  • Soares, Milena B. P; FIOCRUZ. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunofarmacologia.
  • Santos, Ricardo Ribeiro dos; FIOCRUZ. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunofarmacologia.
Mem. Inst. Oswaldo Cruz ; 94(suppl.1): 257-62, Sept. 1999. ilus, graf
Article Dans Anglais | LILACS | ID: lil-245633
ABSTRACT
The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T. cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation.
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cardiomyopathie associée à la maladie de Chagas Limites du sujet: Animaux langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 1999 Type: Article / Congrès et conférence

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cardiomyopathie associée à la maladie de Chagas Limites du sujet: Animaux langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 1999 Type: Article / Congrès et conférence