A survey of congenital Chagas' disease, carried out at three Health Institutions in São Paulo City, Brazil
Rev. Inst. Med. Trop. Säo Paulo
;
41(5): 305-11, Sept.-Oct. 1999. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-250204
ABSTRACT
The congenital transmission of ChagasÆ disease was evaluated in 57 pregnant women with ChagasÆ disease and their 58 offspring. The patients were selected from three Health Institutions in São Paulo City. The maternal clinical forms of ChagasÆ disease were indeterminate (47.4 percent), cardiac (43.8 percent) and digestive (8.8 percent); 55 were born in endemic areas and two in São Paulo City. The transmission of Chagas disease at fetal level was confirmed in three (5.17 percent) of the 58 cases studied and one probably case of congenital ChagasÆ disease. Two infected infants were born to chagasic women with HIV infection and were diagnosed by parasitolological assays (microhematocrit, quantitative buffy coat-QBC or artificial xenodiagnosis). In both cases the placenta revealed T. cruzi and HIV p24 antigens detected by immunohistochemistry. In one case, a 14-week old abortus, the diagnosis of congenital T. cruzi infection was confirmed by immunohistochemistry. The other probable infection, a 30-week old stillborn, the parasites were found in the placenta and umbilical cord. The Western blot method using trypomastigote excreted/secreted antigens of T. cruzi (TESA) was positive for IgG antibodies in 54/55 newborns and for IgM in 1/55 newborns. One of the two newborns with circulating parasites had no detectable IgG or IgM antibodies. The assessment of IgG antibodies in the sera of pregnant women and their newborns was performed by ELISA using two different T. cruzi antigens an alkaline extract of epimastigotes (EAE) and trypomastigote excreted/secreted antigens (TESA). The analysis showed a linear correlation between maternal and newborn IgG antibody titers at birth
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie de Chagas
/
Complications parasitaires de la grossesse
Type d'étude:
Etude diagnostique
/
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. Inst. Med. Trop. Säo Paulo
Thème du journal:
Médecine tropicale
Année:
1999
Type:
Article
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