Studies on the effectiveness of diarylheptanoids derivatives against Leishmania amazonensis
Mem. Inst. Oswaldo Cruz
;
94(6): 791-4, Nov.-Dec. 1999.
Article
Dans Anglais
| LILACS
| ID: lil-251341
ABSTRACT
In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L. amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C. sclerophyllum
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Anti-inflammatoires non stéroïdiens
/
Curcumine
/
Leishmania
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
1999
Type:
Article
Pays d'affiliation:
Brésil
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